GATM Antikörper (C-Term)

Produktnummer ABIN1881365

Produktdetails anti-GATM Antikörper

Target: GATM (Glycine Amidinotransferase (L-Arginine:glycine Amidinotransferase) (GATM))

Bindungsspezifität: AA 350-378, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GATM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, Pr, M, Pig, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GATM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the C-terminal region of human GATM.

Klon: RB41023

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GATM Antikörper (ABIN1881365)

Köttgen, Glazer, Dehghan, Hwang, Katz, Li, Yang, Gudnason, Launer, Harris, Smith, Arking, Astor, Boerwinkle, Ehret, Ruczinski: "Multiple loci associated with indices of renal function and chronic kidney disease." in: Nature genetics, Vol. 41, Issue 6, pp. 712-7, (2010) (PubMed).

Köttgen, Pattaro, Böger, Fuchsberger, Olden, Glazer, Parsa, Gao, Yang, Smith, OConnell, Li, Schmidt, Tanaka, Isaacs, Ketkar, Hwang, Johnson, Dehghan, Teumer, Paré, Atkinson, Zeller, Lohman et al.: "New loci associated with kidney function and chronic kidney disease...." in: Nature genetics, Vol. 42, Issue 5, pp. 376-84, (2010) (PubMed).

Lion-François, Cheillan, Pitelet, Acquaviva-Bourdain, Bussy, Cotton, Guibaud, Gérard, Rivier, Vianey-Saban, Jakobs, Salomons, des Portes: "High frequency of creatine deficiency syndromes in patients with unexplained mental retardation." in: Neurology, Vol. 67, Issue 9, pp. 1713-4, (2006) (PubMed).

Details zu GATM

Target: GATM (Glycine Amidinotransferase (L-Arginine:glycine Amidinotransferase) (GATM))

Andere Bezeichnung: GATM (GATM Produkte)

Synonyme: AT antikoerper, AGAT antikoerper, CCDS3 antikoerper, 1810003P21Rik antikoerper, AI314789 antikoerper, cb409 antikoerper, wu:fa08a06 antikoerper, zgc:65855 antikoerper, glycine amidinotransferase (L-arginine:glycine amidinotransferase) L homeolog antikoerper, glycine amidinotransferase antikoerper, glycine amidinotransferase (L-arginine:glycine amidinotransferase) antikoerper, gatm.L antikoerper, GATM antikoerper, Gatm antikoerper, gatm antikoerper

Hintergrund: This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.

Molekulargewicht: 48455

NCBI Accession: NP_001473

UniProt: P50440