This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This HSPA1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 576-603 amino acids from the C-terminal region of human HSPA1L.
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.