This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This KRT20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 377-401 amino acids from the C-terminal region of human KRT20.
KRT20
Reaktivität: Human
IHC, StM
Wirt: Maus
Monoclonal
KRT20-3145
unconjugated
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Zhou, Cadrin, Herrmann, Chen, Chalkley, Burlingame, Omary: "Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker." in: The Journal of biological chemistry, Vol. 281, Issue 24, pp. 16453-61, (2006) (PubMed).
Calnek, Quaroni: "Differential localization by in situ hybridization of distinct keratin mRNA species during intestinal epithelial cell development and differentiation." in: Differentiation; research in biological diversity, Vol. 53, Issue 2, pp. 95-104, (1993) (PubMed).
Moll, Zimbelmann, Goldschmidt, Keith, Laufer, Kasper, Koch, Franke: "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas." in: Differentiation; research in biological diversity, Vol. 53, Issue 2, pp. 75-93, (1993) (PubMed).
Plays a significant role in maintaining keratin filament organization in intestinal epithelia. When phosphorylated, plays a role in the secretion of mucin in the small intestine (By similarity).