GPR68 Antikörper (AA 200-225)

Produktnummer ABIN1881516

Produktdetails anti-GPR68 Antikörper

Target: GPR68 (G Protein-Coupled Receptor 68 (GPR68))

Bindungsspezifität: AA 200-225

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR68 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Gpr68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GPR68 Antikörper (ABIN1881516)

Frick, Krieger, Nehrke, Bushinsky: "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 2, pp. 305-13, (2009) (PubMed).

Singh, Berk, Oates, Zhao, Tan, Jiang, Zhou, Kirmani, Steinmetz, Lindner, Xu: "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer." in: Journal of the National Cancer Institute, Vol. 99, Issue 17, pp. 1313-27, (2007) (PubMed).

Details zu GPR68

Target: GPR68 (G Protein-Coupled Receptor 68 (GPR68))

Andere Bezeichnung: Gpr68 (GPR68 Produkte)

Synonyme: GPR68 antikoerper, GPR12A antikoerper, OGR1 antikoerper, BB131428 antikoerper, Ogr1 antikoerper, G protein-coupled receptor 68 antikoerper, GPR68 antikoerper, LOC100348269 antikoerper, Gpr68 antikoerper

Hintergrund: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.

Molekulargewicht: 41209

NCBI Accession: NP_001171144, NP_001171145, NP_780702

UniProt: Q8BFQ3