ALIX Antikörper (AA 541-570)

Produktnummer ABIN1881644

Produktdetails anti-ALIX Antikörper

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Bindungsspezifität: AA 541-570

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ALIX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDCD6IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 541-570 amino acids from the Central region of human PDCD6IP.

Klon: RB41924

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ALIX Antikörper (ABIN1881644)

Inuzuka, Suzuki, Kawasaki, Shibata, Wakatsuki, Maki: "Molecular basis for defect in Alix-binding by alternatively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition." in: BMC structural biology, Vol. 10, pp. 25, (2010) (PubMed).

Shi, Opi, Lugari, Restouin, Coursindel, Parrot, Perez, Madore, Zimmermann, Corbeil, Huang, Arold, Collette, Morelli: "Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X." in: The Biochemical journal, Vol. 431, Issue 1, pp. 93-102, (2010) (PubMed).

Irie, Inoue, Sakaguchi: "Significance of the YLDL motif in the M protein and Alix/AIP1 for Sendai virus budding in the context of virus infection." in: Virology, Vol. 405, Issue 2, pp. 334-41, (2010) (PubMed).

Sette, Jadwin, Dussupt, Bello, Bouamr: "The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif." in: Journal of virology, Vol. 84, Issue 16, pp. 8181-92, (2010) (PubMed).

Details zu ALIX

Target: ALIX (PDCD6IP) (Programmed Cell Death 6 Interacting Protein (PDCD6IP))

Andere Bezeichnung: PDCD6IP (PDCD6IP Produkte)

Synonyme: DDBDRAFT_0167145 antikoerper, DDBDRAFT_0185177 antikoerper, DDB_0167145 antikoerper, DDB_0185177 antikoerper, AIP1 antikoerper, ALIX antikoerper, DRIP4 antikoerper, HP95 antikoerper, AI480591 antikoerper, AW544830 antikoerper, Aip1 antikoerper, Alix antikoerper, C76364 antikoerper, Eig2 antikoerper, mKIAA1375 antikoerper, CG12876 antikoerper, DAIP1 antikoerper, Dmel\\CG12876 antikoerper, GB11744 antikoerper, RGD1561176 antikoerper, zgc:63638 antikoerper, wu:fb70d03 antikoerper, wu:fy65h02 antikoerper, PDCD6IP antikoerper, aip1 antikoerper, alix antikoerper, hp95 antikoerper, drip4 antikoerper, ALG-2 interacting protein X antikoerper, programmed cell death 6 interacting protein antikoerper, programmed cell death 6-interacting protein antikoerper, Programmed cell death 6 interacting protein antikoerper, programmed cell death 6 interacting protein L homeolog antikoerper, alxA antikoerper, PDCD6IP antikoerper, Pdcd6ip antikoerper, ALiX antikoerper, LOC412662 antikoerper, pdcd6ip antikoerper, Bm1_48390 antikoerper, pdcd6ip.L antikoerper

Hintergrund: This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Molekulargewicht: 96023

NCBI Accession: NP_001155901, NP_037506

UniProt: Q8WUM4

Pathways: p53 Signalweg, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation