PDE6H Antikörper (AA 4-33)

Produktnummer ABIN1881645

Produktdetails anti-PDE6H Antikörper

Target: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Bindungsspezifität: AA 4-33

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE6H Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, Rat, H

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.

Klon: RB40887

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PDE6H Antikörper (ABIN1881645)

Piri, Gao, Danciger, Mendoza, Fishman, Farber: "A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy." in: Ophthalmology, Vol. 112, Issue 1, pp. 159-66, (2005) (PubMed).

Kajimura, Yamazaki, Morikawa, Yamazaki, Mayanagi: "Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms." in: Journal of structural biology, Vol. 139, Issue 1, pp. 27-38, (2002) (PubMed).

Shimizu-Matsumoto, Itoh, Inazawa, Nishida, Matsumoto, Kinoshita, Matsubara, Okubo: "Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)." in: Genomics, Vol. 32, Issue 1, pp. 121-4, (1996) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Details zu PDE6H

Target: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Andere Bezeichnung: PDE6H (PDE6H Produkte)

Synonyme: ACHM6 antikoerper, RCD3 antikoerper, A930033D18Rik antikoerper, PDEgamma antikoerper, Pde6g antikoerper, phosphodiesterase 6H antikoerper, phosphodiesterase 6H, cGMP-specific, cone, gamma antikoerper, PDE6H antikoerper, Pde6h antikoerper

Hintergrund: This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Molekulargewicht: 9074

NCBI Accession: NP_006196

UniProt: Q13956

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling