PPM1F Antikörper (AA 275-303)

Produktnummer ABIN1881678

Produktdetails anti-PPM1F Antikörper

Target: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Bindungsspezifität: AA 275-303

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PPM1F Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.

Klon: RB41919

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PPM1F Antikörper (ABIN1881678)

Harvey, Banga, Ozer: "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24889-98, (2004) (PubMed).

Koh, Tan, Manser, Lim: "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family." in: Current biology : CB, Vol. 12, Issue 4, pp. 317-21, (2002) (PubMed).

Tan, Chan, Tan, Yu: "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 44193-202, (2001) (PubMed).

Kitani, Ishida, Okuno, Takeuchi, Kameshita, Fujisawa: "Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase." in: Journal of biochemistry, Vol. 125, Issue 6, pp. 1022-8, (1999) (PubMed).

Details zu PPM1F

Target: PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

Andere Bezeichnung: PPM1F (PPM1F Produkte)

Synonyme: 1110021B16Rik antikoerper, 4933427B07Rik antikoerper, CaMKPase antikoerper, Popx2 antikoerper, mKIAA0015 antikoerper, CAMKP antikoerper, FEM-2 antikoerper, POPX2 antikoerper, hFEM-2 antikoerper, protein phosphatase, Mg2+/Mn2+ dependent 1F antikoerper, protein phosphatase 1F (PP2C domain containing) antikoerper, protein phosphatase, Mg2+/Mn2+ dependent, 1F antikoerper, PPM1F antikoerper, Ppm1f antikoerper

Hintergrund: The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

Molekulargewicht: 49831

NCBI Accession: NP_055449

UniProt: P49593

Pathways: Positive Regulation of Endopeptidase Activity