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PROX1 Antikörper (AA 175-206)

PROX1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB15516 unconjugated
Produktnummer ABIN1881686
  • Target Alle PROX1 Antikörper anzeigen
    PROX1 (Prospero Homeobox 1 (PROX1))
    Bindungsspezifität
    • 16
    • 14
    • 9
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 175-206
    Reaktivität
    • 99
    • 53
    • 26
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 91
    • 8
    Kaninchen
    Klonalität
    • 90
    • 9
    Polyklonal
    Konjugat
    • 47
    • 9
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PROX1 Antikörper ist unkonjugiert
    Applikation
    • 81
    • 47
    • 36
    • 28
    • 13
    • 13
    • 12
    • 4
    • 2
    • 2
    Western Blotting (WB)
    Homologie
    M
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This PROX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-206 amino acids from human PROX1.
    Klon
    RB15516
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PROX1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Nagai, Li, Hatano, Toshihito, Yuge, Ito, Utsumi, Saito, Kinoshita: "Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies." in: Genes, chromosomes & cancer, Vol. 38, Issue 1, pp. 13-21, (2003) (PubMed).

    Hong, Harvey, Noh, Schacht, Hirakawa, Detmar, Oliver: "Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 225, Issue 3, pp. 351-7, (2002) (PubMed).

    Petrova, Mäkinen, Mäkelä, Saarela, Virtanen, Ferrell, Finegold, Kerjaschki, Ylä-Herttuala, Alitalo: "Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor." in: The EMBO journal, Vol. 21, Issue 17, pp. 4593-9, (2002) (PubMed).

    Mouta Carreira, Nasser, di Tomaso, Padera, Boucher, Tomarev, Jain: "LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis." in: Cancer research, Vol. 61, Issue 22, pp. 8079-84, (2001) (PubMed).

  • Target
    PROX1 (Prospero Homeobox 1 (PROX1))
    Andere Bezeichnung
    PROX1 (PROX1 Produkte)
    Synonyme
    xprox1 antikoerper, prospero antikoerper, PROX1 antikoerper, LOC100232600 antikoerper, A230003G05Rik antikoerper, prox1 antikoerper, zgc:111888 antikoerper, prospero homeobox 1 antikoerper, prospero homeobox 1 L homeolog antikoerper, prospero homeobox 1a antikoerper, PROX1 antikoerper, prox1.L antikoerper, prox1 antikoerper, Prox1 antikoerper, prox1a antikoerper
    Hintergrund
    The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
    Molekulargewicht
    83203
    NCBI Accession
    NP_001257545, NP_002754
    UniProt
    Q92786
    Pathways
    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation
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