PRTN3 Antikörper (C-Term)

Produktnummer ABIN1881695

Produktdetails anti-PRTN3 Antikörper

Target: PRTN3 (Proteinase 3 (PRTN3))

Bindungsspezifität: AA 228-256, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRTN3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PRTN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-256 amino acids from the C-terminal region of human PRTN3.

Klon: RB40945

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PRTN3 Antikörper (ABIN1881695)

Kuhl, Korkmaz, Utecht, Kniepert, Schönermarck, Specks, Jenne: "Mapping of conformational epitopes on human proteinase 3, the autoantigen of Wegener's granulomatosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 1, pp. 387-99, (2010) (PubMed).

Abdgawad, Gunnarsson, Bengtsson, Geborek, Nilsson, Segelmark, Hellmark: "Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression." in: Clinical and experimental immunology, Vol. 161, Issue 1, pp. 89-97, (2010) (PubMed).

Hajjar, Broemstrup, Kantari, Witko-Sarsat, Reuter: "Structures of human proteinase 3 and neutrophil elastase--so similar yet so different." in: The FEBS journal, Vol. 277, Issue 10, pp. 2238-54, (2010) (PubMed).

Källquist, Rosén, Nordenfelt, Calafat, Janssen, Persson, Hansson, Olsson: "Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells." in: Experimental cell research, Vol. 316, Issue 19, pp. 3182-96, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Details zu PRTN3

Target: PRTN3 (Proteinase 3 (PRTN3))

Andere Bezeichnung: PRTN3 (PRTN3 Produkte)

Synonyme: ela2 antikoerper, MGC132250 antikoerper, ACPA antikoerper, AGP7 antikoerper, C-ANCA antikoerper, CANCA antikoerper, MBN antikoerper, MBT antikoerper, NP-4 antikoerper, NP4 antikoerper, P29 antikoerper, PR-3 antikoerper, PR3 antikoerper, mPR3 antikoerper, proteinase 3 L homeolog antikoerper, proteinase 3 antikoerper, prtn3.L antikoerper, PRTN3 antikoerper, Prtn3 antikoerper

Hintergrund: Polymorphonuclear leukocyte serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) and causes emphysema when administered by tracheal insufflation to hamsters.

Molekulargewicht: 27807

NCBI Accession: NP_002768

UniProt: P24158