PTBP1 Antikörper (N-Term)

Produktnummer ABIN1881702

Produktdetails anti-PTBP1 Antikörper

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Bindungsspezifität: AA 26-55, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PTBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTBP1.

Klon: RB40967

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:4000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PTBP1 Antikörper (ABIN1881702)

Osada, Uno, Mineta, Kameoka, Takahashi, Terao: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." in: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).

Kanda, Gauss-Müller, Cordes, Tamura, Okitsu, Shuang, Nakamoto, Fujiwara, Imazeki, Yokosuka: "Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein." in: Journal of viral hepatitis, Vol. 17, Issue 9, pp. 618-23, (2010) (PubMed).

Verma, Bhattacharyya, Das: "Polypyrimidine tract-binding protein interacts with coxsackievirus B3 RNA and influences its translation." in: The Journal of general virology, Vol. 91, Issue Pt 5, pp. 1245-55, (2010) (PubMed).

Maynard, Hall: "Interactions between PTB RRMs induce slow motions and increase RNA binding affinity." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 260-77, (2010) (PubMed).

Xue, Zhou, Wu, Zhu, Ji, Kwon, Zhang, Yeo, Black, Sun, Fu, Zhang: "Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping." in: Molecular cell, Vol. 36, Issue 6, pp. 996-1006, (2010) (PubMed).

Details zu PTBP1

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Andere Bezeichnung: PTBP1 (PTBP1 Produkte)

Synonyme: HNRNP-I antikoerper, HNRNPI antikoerper, HNRPI antikoerper, PTB antikoerper, PTB-1 antikoerper, PTB-T antikoerper, PTB2 antikoerper, PTB3 antikoerper, PTB4 antikoerper, pPTB antikoerper, Ptb antikoerper, hnrpi antikoerper, hnrnp-I antikoerper, vgrbp60 antikoerper, AA407203 antikoerper, AL033359 antikoerper, Pybp antikoerper, Pybp1 antikoerper, Pybp2 antikoerper, ptbp1 antikoerper, wu:fb99f12 antikoerper, zgc:110689 antikoerper, ptb antikoerper, ATPTB1 antikoerper, POLYPYRIMIDINE TRACT-BINDING antikoerper, POLYPYRIMIDINE TRACT-BINDING PROTEIN 1 antikoerper, T4P13.16 antikoerper, T4P13_16 antikoerper, polypyrimidine tract-binding protein 1 antikoerper, PTBP1 antikoerper, polypyrimidine tract binding protein 1 antikoerper, polypyrimidine tract binding protein 1 S homeolog antikoerper, polypyrimidine tract-binding protein antikoerper, polypyrimidine tract binding protein 1a antikoerper, polypyrimidine tract binding protein 1 L homeolog antikoerper, polypyrimidine tract-binding protein 1 antikoerper, PTBP1 antikoerper, ptbp1.S antikoerper, NAEGRDRAFT_80143 antikoerper, LOC100285404 antikoerper, Ptbp1 antikoerper, ptbp1a antikoerper, ptbp1.L antikoerper, PTB1 antikoerper, LOC100061673 antikoerper

Hintergrund: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Molekulargewicht: 57221

NCBI Accession: NP_002810, NP_114367, NP_114368

UniProt: P26599

Pathways: Regulation of Muscle Cell Differentiation