Dieser Poliovirus Receptor Antikörper ist unkonjugiert
Applikation
Western Blotting (WB)
Aufreinigung
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This PVR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human PVR.
PVR
Reaktivität: Human
WB
Wirt: Kaninchen
Monoclonal
unconjugated
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Nakai, Maniwa, Tanaka, Nishio, Yoshimura, Okita, Ohbayashi, Satoh, Ogita, Takai, Hayashi: "Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma." in: Cancer science, Vol. 101, Issue 5, pp. 1326-30, (2010) (PubMed).
Carlsten, Norell, Bryceson, Poschke, Schedvins, Ljunggren, Kiessling, Malmberg: "Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 8, pp. 4921-30, (2009) (PubMed).
Kindberg, Ax, Fiore, Svensson: "Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis." in: Journal of medical virology, Vol. 81, Issue 5, pp. 933-6, (2009) (PubMed).
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.