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CDK4 Antikörper (C-Term)

Name: CDK4 Antikörper (C-Term)
SKU: ABIN1881714
Price: 467.5 EUR
Availability: InStock

CDK4 Reaktivität: Ratte WB, IF, IHC (p) Wirt: Kaninchen Polyclonal unconjugated

Rat Cdk4 Antibody (C-term) (ABIN1881714 and ABIN2843623) western blot analysis in rat lung tissue lysates (35 μg/lane). (CDK4 Antikörper (C-Term))

Immunohistochemical analysis of paraffin-embedded rat small intestine section using Rat Cdk4 Antibody (C-term) B. (CDK4 Antikörper (C-Term))

IHC (p)

Fluorescent image of MCF-7 cells stained with (Rat) Cdk4 Antibody (C-term) B. (CDK4 Antikörper (C-Term))

Immunohistochemical analysis of paraffin-embedded R. (CDK4 Antikörper (C-Term))

IHC (p)

4 Abbildungen

(1 reference)

Produktnummer ABIN1881714

Datenblatt (PDF)

Target Alle CDK4 Antikörper anzeigen

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
Bindungsspezifität
16

16

14

9

9

8

5

4

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1
AA 272-303, C-Term
Reaktivität
113

63

51

19

7

6

4

3

2

1

1

1
Ratte
Wirt
92

36

2

1
Kaninchen
Passende Sekundärantikörper
Klonalität
91

39
Polyklonal
Konjugat
80

9

8

5

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser CDK4 Antikörper ist unkonjugiert
Applikation
108

45

32

24

21

15

15

14

13

10

7

4

2

2

1

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This Rat Cdk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-303 amino acids from the C-terminal region of rat Cdk4.

Isotyp

Ig Fraction

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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303) antibody
CDK4 Reaktivität: Human, Ratte ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (N-Term) antibody
CDK4 Reaktivität: Human, Maus, Ratte, Hund WB, IP, IHC (fro), BI Wirt: Maus Monoclonal DCS-35 unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (C-Term) antibody
CDK4 Reaktivität: Human, Ratte, Schaf, Schwein, Hund, Rind (Kuh), Kaninchen, Meerschweinchen, Pferd WB, IHC Wirt: Kaninchen Polyclonal unconjugated

Applikationshinweise

IF: 1:25. WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Haltbarkeit

6 months
Cho, Phillips, Khan, Weaver: "Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues." in: Biochemical and biophysical research communications, Vol. 191, Issue 3, pp. 860-5, (1993) (PubMed).
Target

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Andere Bezeichnung

Cdk4 (CDK4 Produkte)

Hintergrund

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Molekulargewicht

33799

NCBI Accession

NP_446045

UniProt

P35426

Pathways

Zellzyklus, Mitotic G1-G1/S Phases, Regulation of Cell Size