This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RFFL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human RFFL.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).
Newton-Cheh, Eijgelsheim, Rice, de Bakker, Yin, Estrada, Bis, Marciante, Rivadeneira, Noseworthy, Sotoodehnia, Smith, Rotter, Kors, Witteman, Hofman, Heckbert: "Common variants at ten loci influence QT interval duration in the QTGEN Study." in: Nature genetics, Vol. 41, Issue 4, pp. 399-406, (2009) (PubMed).
Hosgood, Zhang, Shen, Berndt, Vermeulen, Li, Yin, Yeager, Yuenger, Rothman, Chanock, Smith, Lan: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, (2009) (PubMed).
Liao, Xiao, Tchikov, Fujita, Yang, Wincovitch, Garfield, Conze, El-Deiry, Schütze, Srinivasula: "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation." in: Current biology : CB, Vol. 18, Issue 9, pp. 641-9, (2008) (PubMed).
Yang, Dicker, Chen, El-Deiry: "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2." in: Cell cycle (Georgetown, Tex.), Vol. 7, Issue 5, pp. 670-82, (2008) (PubMed).
Target
RFFL
(Ring Finger and FYVE-Like Domain Containing 1 (RFFL))
MGC84042 antikoerper, RFFL antikoerper, Rffl antikoerper, 1700051E09Rik antikoerper, 4930516L10Rik antikoerper, BG080975 antikoerper, Carp2 antikoerper, CARP-2 antikoerper, CARP2 antikoerper, FRING antikoerper, RIFIFYLIN antikoerper, RNF189 antikoerper, RNF34L antikoerper, ring finger and FYVE like domain containing E3 ubiquitin protein ligase antikoerper, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase L homeolog antikoerper, ring finger and FYVE-like domain containing 1 antikoerper, ring finger and FYVE like domain containing protein antikoerper, ring finger and FYVE-like domain containing E3 ubiquitin protein ligase antikoerper, RFFL antikoerper, rffl.L antikoerper, Rffl antikoerper
Hintergrund
RFFL has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.