This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This RNF135 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-401 amino acids from the C-terminal region of human RNF135.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
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You, Sun, Zhou, Sun, Liang, Zhai, Jiang: "PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4." in: Nature immunology, Vol. 10, Issue 12, pp. 1300-8, (2009) (PubMed).
Oshiumi, Matsumoto, Hatakeyama, Seya: "Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection." in: The Journal of biological chemistry, Vol. 284, Issue 2, pp. 807-17, (2009) (PubMed).
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].