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SGOL2 Antikörper (AA 391-419)

SGOL2 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB42663 unconjugated
Produktnummer ABIN1881800
  • Target Alle SGOL2 Antikörper anzeigen
    SGOL2 (Shugoshin-Like 2 (SGOL2))
    Bindungsspezifität
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 391-419
    Reaktivität
    • 12
    • 1
    Human
    Wirt
    • 12
    Kaninchen
    Klonalität
    • 12
    Polyklonal
    Konjugat
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SGOL2 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.
    Klon
    RB42663
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." in: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).

    Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

    Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." in: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).

    Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." in: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).

    Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." in: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).

  • Target
    SGOL2 (Shugoshin-Like 2 (SGOL2))
    Andere Bezeichnung
    SGOL2 (SGOL2 Produkte)
    Synonyme
    SGO2 antikoerper, TRIPIN antikoerper, 1110007N04Rik antikoerper, 4932411A20Rik antikoerper, 5730576N04Rik antikoerper, AU018846 antikoerper, AV008062 antikoerper, D1Ertd8e antikoerper, Tripin antikoerper, shugoshin 2 antikoerper, shugoshin 2A antikoerper, SGO2 antikoerper, Sgo2a antikoerper
    Hintergrund
    Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.
    Molekulargewicht
    144739
    NCBI Accession
    NP_001153518, NP_689737
    UniProt
    Q562F6
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