This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This Mouse Shc4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 590-617 amino acids from the C-terminal region of mouse Shc4.
SHC4
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Jones, Hardy, Friese, Jorgensen, Smith, Woody, Burden, Pawson: "Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase." in: Molecular and cellular biology, Vol. 27, Issue 13, pp. 4759-73, (2007) (PubMed).
Fagiani, Giardina, Luzi, Cesaroni, Quarto, Capra, Germano, Bono, Capillo, Pelicci, Lanfrancone: "RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas." in: Cancer research, Vol. 67, Issue 7, pp. 3064-73, (2007) (PubMed).
Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1.