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T Antigen (AA 15-43), (N-Term) Antikörper

Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal RB41833 unconjugated
Produktnummer ABIN1881864
  • Target
    T Antigen
    Bindungsspezifität
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 15-43, N-Term
    Reaktivität
    • 17
    • 2
    Human
    Wirt
    • 10
    • 8
    Kaninchen
    Klonalität
    • 11
    • 7
    Polyklonal
    Konjugat
    • 13
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 17
    • 10
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Homologie
    Chicken,Mouse (Murine)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
    Immunogen
    This T antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the N-terminal region of human T.
    Klon
    RB41833
  • Applikationshinweise
    WB: 1:1000,IF: 1:10-50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.39 mg/mL
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
  • Jambhekar, Rekhi, Thorat, Dikshit, Agrawal, Puri: "Revisiting chordoma with brachyury, a \new age\" marker: analysis of a validation study on 51 cases."" in: Archives of pathology & laboratory medicine, Vol. 134, Issue 8, pp. 1181-7, (2010) (PubMed).

    Yang, Ng, Alcorta, Liebsch, Sheridan, Li, Goldstein, Parry, Kelley: "T (brachyury) gene duplication confers major susceptibility to familial chordoma." in: Nature genetics, Vol. 41, Issue 11, pp. 1176-8, (2009) (PubMed).

    Bondue, Lapouge, Paulissen, Semeraro, Iacovino, Kyba, Blanpain: "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification." in: Cell stem cell, Vol. 3, Issue 1, pp. 69-84, (2008) (PubMed).

    Oakley, Fuhrer, Seethala: "Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 12, pp. 1461-9, (2008) (PubMed).

  • Target
    T Antigen
    Hintergrund
    The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.

    Synonyms: T, Brachyury protein, Protein T
    NCBI Accession
    NP_003172, NP_001257413
    UniProt
    O15178
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