TSC1 Antikörper (pThr417)

Produktnummer ABIN1881908

Produktdetails anti-TSC1 Antikörper

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Bindungsspezifität: pThr417

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSC1 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T417 of rat TSC1.

Klon: RB41269

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-TSC1 Antikörper (ABIN1881908)

Inoue, Ndong, Suzuki, Kazami, Uyama, Kobayashi, Tadokoro, Yamamoto: "Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock." in: Bioscience, biotechnology, and biochemistry, Vol. 73, Issue 11, pp. 2488-93, (2009) (PubMed).

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, (2009) (PubMed).

Chen, Yan, Chen, He: "The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats." in: Experimental and molecular pathology, Vol. 86, Issue 2, pp. 101-7, (2009) (PubMed).

Momose, Kobayashi, Tada, Itoyama, Hino: "N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 693-8, (2007) (PubMed).

Details zu TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Andere Bezeichnung: TSC1 (TSC1 Produkte)

Synonyme: LAM antikoerper, TSC antikoerper, hamartin antikoerper, mKIAA0243 antikoerper, tsc1 antikoerper, wu:fc38b04 antikoerper, fa99f04 antikoerper, wu:fa99f04 antikoerper, zgc:63657 antikoerper, TSC complex subunit 1 antikoerper, tuberous sclerosis 1 antikoerper, TSC complex subunit 1b antikoerper, TSC complex subunit 1a antikoerper, TSC1 antikoerper, Tsc1 antikoerper, tsc1b antikoerper, tsc1 antikoerper, tsc1a antikoerper

Hintergrund: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Molekulargewicht: 129022

NCBI Accession: NP_068626

UniProt: Q9Z136

Pathways: RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation