UGT2B28 Antikörper (AA 218-246)

Produktnummer ABIN1881976

Produktdetails anti-UGT2B28 Antikörper

Target: UGT2B28 (UDP Glucuronosyltransferase 2 Family, Polypeptide B28 (UGT2B28))

Bindungsspezifität: AA 218-246

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UGT2B28 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: Pr

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This UGT2B28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human UGT2B28.

Klon: RB41660

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-UGT2B28 Antikörper (ABIN1881976)

Setlur, Chen, Hossain, Ha, Van Doren, Stenzel, Steiner, Oldridge, Kitabayashi, Banerjee, Chen, Schäfer, Horninger, Lee, Rubin, Klocker, Demichelis: "Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 1, pp. 229-39, (2010) (PubMed).

Ménard, Eap, Harvey, Guillemette, Lévesque: "Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism." in: Human mutation, Vol. 30, Issue 9, pp. 1310-9, (2009) (PubMed).

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Lévesque, Turgeon, Carrier, Montminy, Beaulieu, Bélanger: "Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase." in: Biochemistry, Vol. 40, Issue 13, pp. 3869-81, (2001) (PubMed).

Details zu UGT2B28

Target: UGT2B28 (UDP Glucuronosyltransferase 2 Family, Polypeptide B28 (UGT2B28))

Andere Bezeichnung: UGT2B28 (UGT2B28 Produkte)

Hintergrund: UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme has glucuronidating capacity with steroid substrates such as 5-beta-androstane 3-alpha,17-beta-diol, estradiol, ADT, eugenol and bile acids. Only isoform 1 seems to be active.

Molekulargewicht: 60906

NCBI Accession: NP_001193933, NP_444267

UniProt: Q9BY64

Pathways: Steroid Hormone Biosynthesis