ULK1 Antikörper (pSer317)

Produktnummer ABIN1881978

Produktdetails anti-ULK1 Antikörper

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Bindungsspezifität: pSer317

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ULK1 Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ULK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S317 of human ULK1.

Klon: RB40755

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ULK1 Antikörper (ABIN1881978)

Mercer, Kaliappan, Dennis: "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy." in: Autophagy, Vol. 5, Issue 5, pp. 649-62, (2009) (PubMed).

Ganley, Lam, Wang, Ding, Chen, Jiang: "ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12297-305, (2009) (PubMed).

Jung, Jun, Ro, Kim, Otto, Cao, Kundu, Kim: "ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery." in: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1992-2003, (2009) (PubMed).

Hosokawa, Hara, Kaizuka, Kishi, Takamura, Miura, Iemura, Natsume, Takehana, Yamada, Guan, Oshiro, Mizushima: "Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy." in: Molecular biology of the cell, Vol. 20, Issue 7, pp. 1981-91, (2009) (PubMed).

Details zu ULK1

Target: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Andere Bezeichnung: ULK1 (ULK1 Produkte)

Hintergrund: Involved in autophagy. Required for autophagosome formation (By similarity). Target of the TOR kinase signaling pathway that regulates autophagy through the control of phosphorylation status of ATG13/KIAA0652 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex (By similarity). Phosphorylates ATG13/KIAA0652. Involved in axon growth (By similarity). Plays an essential role in neurite extension of cerebellar granule cells (By similarity).

Molekulargewicht: 112631

NCBI Accession: NP_003556

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagie