FKBP1A Antikörper (C-Term)

Produktnummer ABIN1882082

Produktdetails anti-FKBP1A Antikörper

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Bindungsspezifität: AA 55-83, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FKBP1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Rb

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This FKBP1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the C-terminal region of human FKBP1A.

Klon: RB19307

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-FKBP1A Antikörper (ABIN1882082)

Gerard, Debyser, Desender, Baert, Brandt, Baekelandt, Engelborghs: "FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T." in: Journal of neurochemistry, Vol. 106, Issue 1, pp. 121-33, (2008) (PubMed).

Shor, Zhang, Toral-Barza, Lucas, Abraham, Gibbons, Yu: "A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis." in: Cancer research, Vol. 68, Issue 8, pp. 2934-43, (2008) (PubMed).

Details zu FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Andere Bezeichnung: FKBP1A (FKBP1A Produkte)

Hintergrund: FKBP12 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium.

Molekulargewicht: 11951

NCBI Accession: NP_000792, NP_463460

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process