GRK4 Antikörper (C-Term)

Produktnummer ABIN1882085

Produktdetails anti-GRK4 Antikörper

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Bindungsspezifität: AA 549-577, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This GRK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-577 amino acids from the C-terminal region of human GRK4.

Klon: RB0901

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GRK4 Antikörper (ABIN1882085)

Villar, Jones, Armando, Palmes-Saloma, Yu, Pascua, Keever, Arnaldo, Wang, Luo, Felder, Jose: "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21425-34, (2009) (PubMed).

Perroy, Adam, Qanbar, Chénier, Bouvier: "Phosphorylation-independent desensitization of GABA(B) receptor by GRK4." in: The EMBO journal, Vol. 22, Issue 15, pp. 3816-24, (2003) (PubMed).

Watanabe, Xu, Bengra, Jose, Felder: "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4." in: Kidney international, Vol. 62, Issue 3, pp. 790-8, (2002) (PubMed).

Sallese, Mariggiò, Collodel, Moretti, Piomboni, Baccetti, De Blasi: "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10188-95, (1997) (PubMed).

Premont, Macrae, Stoffel, Chung, Pitcher, Ambrose, Inglese, MacDonald, Lefkowitz: "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants." in: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6403-10, (1996) (PubMed).

Sallese, Lombardi, De Blasi: "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning." in: Biochemical and biophysical research communications, Vol. 199, Issue 2, pp. 848-54, (1994) (PubMed).

Details zu GRK4

Target: GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

Andere Bezeichnung: GRK4 (GRK4 Produkte)

Synonyme: GPRK2L antikoerper, GPRK4 antikoerper, GRK4a antikoerper, IT11 antikoerper, A830025H08Rik antikoerper, GRK antikoerper, Gprk2l antikoerper, Gprk4 antikoerper, AMPK antikoerper, AMPKalpha antikoerper, CG3051 antikoerper, DmAMPK alpha antikoerper, Dmel\\CG3051 antikoerper, EG:132E8.2 antikoerper, FBgn0023169 antikoerper, Gprk-4 antikoerper, ampk antikoerper, ampkalpha antikoerper, dAMPKa antikoerper, dAMPKalpha antikoerper, snf1a antikoerper, gprk4 antikoerper, gprk4-a antikoerper, grk4 antikoerper, GRK4 antikoerper, gprk4-b antikoerper, zgc:153020 antikoerper, gprk2l antikoerper, grk4a antikoerper, it11 antikoerper, G protein-coupled receptor kinase 4 antikoerper, AMP-activated protein kinase alpha subunit antikoerper, G protein-coupled receptor kinase 4 L homeolog antikoerper, G protein-coupled receptor kinase 4 S homeolog antikoerper, GRK4 antikoerper, Grk4 antikoerper, AMPKalpha antikoerper, grk4.L antikoerper, grk4.S antikoerper, grk4 antikoerper, LOC100540688 antikoerper

Hintergrund: Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

Molekulargewicht: 66583

NCBI Accession: NP_001004056, NP_001004057, NP_892027

UniProt: P32298

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling