DNAJB1 Antikörper

Produktnummer ABIN1882092

Produktdetails anti-DNAJB1 Antikörper

Target: DNAJB1 (DnaJ (Hsp40) Homolog, Subfamily B, Member 1 (DNAJB1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DNAJB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HSP40 antibody is generated from rabbits immunized with a recombinant protein encoding full length of human HSP40.

Klon: RB1770

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:4000. IHC-P: 1:50~100. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-DNAJB1 Antikörper (ABIN1882092)

Ohtsuka, Hata: "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature." in: Cell stress & chaperones, Vol. 5, Issue 2, pp. 98-112, (2001) (PubMed).

Hata, Ohtsuka: "Characterization of HSE sequences in human Hsp40 gene: structural and promoter analysis." in: Biochimica et biophysica acta, Vol. 1397, Issue 1, pp. 43-55, (1998) (PubMed).

Hata, Okumura, Seto, Ohtsuka: "Genomic cloning of a human heat shock protein 40 (Hsp40) gene (HSPF1) and its chromosomal localization to 19p13.2." in: Genomics, Vol. 38, Issue 3, pp. 446-9, (1997) (PubMed).

Details zu DNAJB1

Target: DNAJB1 (DnaJ (Hsp40) Homolog, Subfamily B, Member 1 (DNAJB1))

Andere Bezeichnung: HSP40 (DNAJB1 Produkte)

Synonyme: HSPF1 antikoerper, Hdj1 antikoerper, Hsp40 antikoerper, RSPH16B antikoerper, Sis1 antikoerper, CG10578 antikoerper, DNAJ-1 antikoerper, DNAJ1 antikoerper, DROJ1 antikoerper, Dmel\\CG10578 antikoerper, DnaJ1 64EF antikoerper, DroJ1 antikoerper, EU3500 antikoerper, HSP40 antikoerper, HSP40/HDJ1 antikoerper, Hsp-40 antikoerper, anon-WO0140519.166 antikoerper, anon-WO0172774.135 antikoerper, dHDJ1 antikoerper, dHDJ1/HSP40 antikoerper, dHdj1 antikoerper, dhdJ1 antikoerper, dhdj-1 antikoerper, dhdj1 antikoerper, dnaJ-1 antikoerper, droj1 antikoerper, hsp40 antikoerper, dnajb4 antikoerper, hdj1 antikoerper, hspf1 antikoerper, sis1 antikoerper, DnaJ-5 antikoerper, MAS5 antikoerper, dnaJ antikoerper, 0610007I11Rik antikoerper, dnajb1 antikoerper, zf-Hsp40 antikoerper, zgc:101068 antikoerper, DnaJ heat shock protein family (Hsp40) member B1 antikoerper, DnaJ-like-1 antikoerper, DnaJ (Hsp40) homolog 5 antikoerper, type I HSP40 co-chaperone YDJ1 antikoerper, DnaJ protein antikoerper, molecular chaperone DnaJ antikoerper, DnaJ (Hsp40) homolog, subfamily B, member 1a antikoerper, DNAJB1 antikoerper, Dnajb1 antikoerper, DnaJ-1 antikoerper, dnajb1 antikoerper, DnaJ-5 antikoerper, YDJ1 antikoerper, dnaJ antikoerper, dnajb1a antikoerper

Hintergrund: DnaJ (Hsp40) belongs to the DnaJ-class of molecular chaperones with a C-terminal Zn finger domain. HSP40 (DnaJ) together with DnaK and GrpE form a molecular chaperone that is involved in formation of protein complexes, protein folding, prevention of protein aggregation, and protein turnover and export. Several human neurodegenerative diseases involve the expansion of a polyglutamine within the disease proteins. Molecular chaperones such as HSP40 complexes can modulate polyglutamine pathogenesis In transgenic Drosophila disease models of Machado-Joseph disease and Huntington disease Hdj1, the Drosophila homolog to human HSP40, demonstrates substrate specificity for polyglutamine proteins suppression in combination with other molecular chapterones of neurotoxicity, and altered solubility of mutant polyglutamine proteins.

Molekulargewicht: 38044

NCBI Accession: NP_006136

UniProt: P25685