This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This PTP1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.
PTPN1
Reaktivität: Human
WB, IP
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Trümpler, Schlott, Herrlich, Greer, Böhmer: "Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B." in: The FEBS journal, Vol. 276, Issue 19, pp. 5622-33, (2009) (PubMed).
Xu, Li, Qian, Hong, Shen, Huang: "Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter." in: Biochemical and biophysical research communications, Vol. 329, Issue 2, pp. 538-43, (2005) (PubMed).
Blincoe, Chidambaram, Salari, Bond, Evans, Gray-Kaufman, Griffey, Tranby, Garner-Johnson, Lee, Sorenson: "Pharmacokinetic distribution of 67Cu(II)2[3,5-diisopropyl(carboxy-14C)salicylate]4 among murine tissues." in: Current medicinal chemistry, Vol. 11, Issue 22, pp. 3007-15, (2004) (PubMed).
Kipfer-Coudreau, Eberlé, Sahbatou, Bonhomme, Guy-Grand, Froguel, Galan, Basdevant, Clément: "Single nucleotide polymorphisms of protein tyrosine phosphatase 1B gene are associated with obesity in morbidly obese French subjects." in: Diabetologia, Vol. 47, Issue 7, pp. 1278-84, (2004) (PubMed).
Palmer, Bento, Mychaleckyj, Langefeld, Campbell, Norris, Haffner, Bergman, Bowden: "Association of protein tyrosine phosphatase 1B gene polymorphisms with measures of glucose homeostasis in Hispanic Americans: the insulin resistance atherosclerosis study (IRAS) family study." in: Diabetes, Vol. 53, Issue 11, pp. 3013-9, (2004) (PubMed).
Target
PTPN1
(Protein tyrosine Phosphatase, Non-Receptor Type 1 (PTPN1))
PTPN1 antikoerper, PTP1B antikoerper, PTP-1B antikoerper, PTP-HA2 antikoerper, Ptp antikoerper, ptp1b antikoerper, wu:fk54h03 antikoerper, CPTP1 antikoerper, protein tyrosine phosphatase, non-receptor type 1 antikoerper, protein tyrosine phosphatase, non-receptor type 1 L homeolog antikoerper, PTPN1 antikoerper, Ptpn1 antikoerper, ptpn1 antikoerper, ptpn1.L antikoerper
Hintergrund
PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.