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TK2 Antikörper (N-Term)

TK2 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal RB5434 unconjugated
Produktnummer ABIN1882141
  • Target Alle TK2 Antikörper anzeigen
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Bindungsspezifität
    AA 8-38, N-Term
    Reaktivität
    Human, Maus
    Wirt
    Kaninchen
    Klonalität
    Polyklonal
    Applikation
    Western Blotting (WB)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
    Klon
    RB5434
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Target
    TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
    Abstract
    TK2 Produkte
    Synonyme
    MTDPS2 antikoerper, MTTK antikoerper, AU024611 antikoerper, mt-TK antikoerper, tk2 antikoerper, zgc:100948 antikoerper, thymidine kinase 2, mitochondrial antikoerper, thymidine kinase 2, mitochondrial S homeolog antikoerper, TK2 antikoerper, Tk2 antikoerper, tk2.S antikoerper, tk2 antikoerper
    Hintergrund
    Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
    Molekulargewicht
    31005
    NCBI Accession
    NP_001166114, NP_001166115, NP_001258864, NP_004605
    UniProt
    O00142
    Pathways
    Mitotic G1-G1/S Phases
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