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TYMS Antikörper (C-Term)

Name: TYMS Antikörper (C-Term)
SKU: ABIN1882144
Price: 445.5 EUR
Availability: InStock

TYMS Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB20041 unconjugated

Western blot analysis of lysate from Jurkat cell line, using TYSY Antibody (C-term) (ABIN1882144 and ABIN2840937). (TYMS Antikörper (C-Term))

Flow cytometric analysis of WiDr cells using TYSY Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). (TYMS Antikörper (C-Term))

FACS

Confocal immunofluorescent analysis of TYSY Antibody (C-term) (ABIN1882144 and ABIN2840937) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (TYMS Antikörper (C-Term))

Formalin-fixed and paraffin-embedded human colon carcinoma with TYSY Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (TYMS Antikörper (C-Term))

IHC (p)

4 Abbildungen

(3 Referenzen)

Produktnummer ABIN1882144

Datenblatt (PDF)

Target Alle TYMS Antikörper anzeigen

TYMS (Thymidylate Synthetase (TYMS))
Bindungsspezifität
15

12

6

5

3

3

3

1

1

1

1

1
AA 265-294, C-Term
Reaktivität
97

29

14

3

2

2

2

1

1

1
Human
Wirt
54

42

1
Kaninchen
Passende Sekundärantikörper
Klonalität
49

48
Polyklonal
Konjugat
45

7

4

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser TYMS Antikörper ist unkonjugiert
Applikation
50

41

33

22

19

19

18

16

14

13

9

7

6

3

3

2

2

1

1
Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This TYSY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-294 amino acids from the C-terminal region of human TYSY.

Klon

RB20041

Isotyp

Ig Fraction

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anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibody
TYMS Reaktivität: Human WB, IF, ELISA, IHC (p) Wirt: Maus Monoclonal 3A1 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reaktivität: Human WB, IF, IHC (p), IP, ICC Wirt: Kaninchen Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibody
TYMS Reaktivität: Human WB, IF, FACS, IHC, ISt, RIA, StM Wirt: Maus Monoclonal TYMS-1884 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 1D6 unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 5H8 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 111-210) antibody
TYMS Reaktivität: Human WB, ELISA, IHC (p), IP Wirt: Maus Monoclonal 2B2 unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 2-54) antibody
TYMS Reaktivität: Human WB, IF, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) antibody
TYMS Reaktivität: Human, Maus, Ratte IF Wirt: Kaninchen Polyclonal unconjugated

anti-Thymidylate Synthetase (TYMS) (AA 60-174) antibody
TYMS Reaktivität: Human IF, FACS, ELISA, RIA, Coat Wirt: Maus Monoclonal rTYMS-1884 unconjugated Recombinant Antibody

Applikationshinweise

IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Haltbarkeit

6 months
Ma, He, Zhang, Fei, Niu, Wang, Ding, Xu, Chen, Zhu: "DNA methylation-regulated miR-193a-3p dictates resistance of hepatocellular carcinoma to 5-fluorouracil via repression of SRSF2 expression." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 5639-49, (2012) (PubMed).

Ren, Kim, Koh, Chang, Eom, Yi, Seong, Kim, Bronner, Cho: "Comparative analysis of thymidylate synthase at the protein, mRNA, and DNA levels as prognostic markers in colorectal adenocarcinoma." in: Journal of surgical oncology, Vol. 100, Issue 7, pp. 546-52, (2009) (PubMed).

Schiffer, Clifton, Davisson, Santi, Stroud: "Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site." in: Biochemistry, Vol. 34, Issue 50, pp. 16279-87, (1996) (PubMed).
Target

TYMS (Thymidylate Synthetase (TYMS))

Abstract

TYMS Produkte

Synonyme

FN1 antikoerper, ECK2823 antikoerper, JW2795 antikoerper, ts antikoerper, Ts antikoerper, HST422 antikoerper, TMS antikoerper, TS antikoerper, thymidylate synthetase antikoerper, contains intron in T4 phage antikoerper, ThyE antikoerper, thymidylate synthase antikoerper, thymidylate synthetase L homeolog antikoerper, TYMS antikoerper, thyA antikoerper, td antikoerper, thyE antikoerper, DDA3937_RS04960 antikoerper, tyms.L antikoerper, XBJ1_RS15770 antikoerper, EAMY_RS20680 antikoerper, Tyms antikoerper

Hintergrund

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

Molekulargewicht

35716

NCBI Accession

NP_001062

UniProt

P04818

Pathways

Mitotic G1-G1/S Phases