YWHAB Antikörper (N-Term)

Produktnummer ABIN1882154

Produktdetails anti-YWHAB Antikörper

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Bindungsspezifität: AA 56-85, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YWHAB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: B, Pr, M, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human YWHAB.

Klon: RB4062

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-YWHAB Antikörper (ABIN1882154)

Tang, Lv, Sun, Han, Zhou: "14-3-3β Promotes Migration and Invasion of Human Hepatocellular Carcinoma Cells by Modulating Expression of MMP2 and MMP9 through PI3K/Akt/NF-κB Pathway." in: PLoS ONE, Vol. 11, Issue 1, pp. e0146070, (2016) (PubMed).

Yang, Thein, Wang, Bi, Ericksen, Xu, Han: "BSCL2/seipin regulates adipogenesis through actin cytoskeleton remodelling." in: Human molecular genetics, Vol. 23, Issue 2, pp. 502-13, (2013) (PubMed).

Yue, Song, Ma, Feng, Guan, Wu, Yang, Jiang, Liu, Cui, Guo: "Effects of triterpenes from Ganoderma lucidum on protein expression profile of HeLa cells." in: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 17, Issue 8-9, pp. 606-13, (2010) (PubMed).

Komori, Ishizawa, Arai, Hirose, Mizutani, Oda: "Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy." in: Acta neuropathologica, Vol. 106, Issue 1, pp. 66-70, (2003) (PubMed).

Cavet, Lehoux, Berk: "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18376-83, (2003) (PubMed).

Li, Inoki, Vacratsis, Guan: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, (2003) (PubMed).

Shumway, Li, Xiong: "14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2089-92, (2003) (PubMed).

Parvaresch, Yesilkaya, Baer, Al-Hasani, Klein: "14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation." in: FEBS letters, Vol. 532, Issue 3, pp. 357-62, (2002) (PubMed).

Details zu YWHAB

Target: YWHAB (14-3-3 alpha + beta (YWHAB))

Andere Bezeichnung: YWHAB (YWHAB Produkte)

Synonyme: GW128 antikoerper, HS1 antikoerper, KCIP-1 antikoerper, YWHAA antikoerper, 1300003C17Rik antikoerper, wu:fb22g04 antikoerper, wu:fr86a12 antikoerper, ywhab antikoerper, ywhab2 antikoerper, zgc:64092 antikoerper, 14-3-3beta antikoerper, fb80c08 antikoerper, fk41f08 antikoerper, wu:fb80c08 antikoerper, wu:fd11d01 antikoerper, wu:fk41f08 antikoerper, ywhab1 antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta S homeolog antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta L homeolog antikoerper, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a antikoerper, YWHAB antikoerper, Ywhab antikoerper, ywhabb antikoerper, ywhab.S antikoerper, ywhab.L antikoerper, ywhaba antikoerper

Hintergrund: YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

Molekulargewicht: 28082

NCBI Accession: NP_003395, NP_647539

UniProt: P31946

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Myometrial Relaxation and Contraction, Maintenance of Protein Location