ATG3 Antikörper (C-Term)

Produktnummer ABIN1882157

Produktdetails anti-ATG3 Antikörper

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Bindungsspezifität: AA 168-197, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human ATG3.

Klon: RB7459

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ATG3 Antikörper (ABIN1882157)

Radoshevich, Murrow, Chen, Fernandez, Roy, Fung, Debnath: "ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death." in: Cell, Vol. 142, Issue 4, pp. 590-600, (2010) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Details zu ATG3

Target: ATG3 (ATG3 Autophagy Related 3 (ATG3))

Andere Bezeichnung: ATG3 (ATG3 Produkte)

Hintergrund: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG3L is an E2-like conjugating enzyme facilitating covalent binding of APG8 (MAP1LC3) to phosphatidylethanolamine (PE). APG7 (an E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with APG3. Formation of the PE conjugate is essential for autophagy.

Molekulargewicht: 35864

NCBI Accession: NP_001265641, NP_071933

UniProt: Q9NT62

Pathways: Autophagie