GSG2 Antikörper (AA 323-352)

Produktnummer ABIN1882168

Produktdetails anti-GSG2 Antikörper

Target: GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))

Bindungsspezifität: AA 323-352

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GSG2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Haspin GSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323~352 amino acids from the central region of human haspin.

Klon: RB3404

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-GSG2 Antikörper (ABIN1882168)

Dai, Sultan, Taylor, Higgins: "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment." in: Genes & development, Vol. 19, Issue 4, pp. 472-88, (2005) (PubMed).

Higgins: "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells." in: Gene, Vol. 267, Issue 1, pp. 55-69, (2001) (PubMed).

Tanaka, Iguchi, Nakamura, Kohroki, de Carvalho, Nishimune: "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase." in: Molecular human reproduction, Vol. 7, Issue 3, pp. 211-8, (2001) (PubMed).

Details zu GSG2

Target: GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))

Andere Bezeichnung: Haspin GSG2 (GSG2 Produkte)

Synonyme: BcDNA:LD07633 antikoerper, CG40080 antikoerper, Dmel\\CG40080 antikoerper, haspin antikoerper, NV16901 antikoerper, HASPIN antikoerper, Haspin antikoerper, putative serine/threonine-protein kinase haspin homolog antikoerper, histone H3 associated protein kinase antikoerper, CG40080 gene product from transcript CG40080-RA antikoerper, uncharacterized LOC100122327 antikoerper, LOC552287 antikoerper, HASPIN antikoerper, Haspin antikoerper, LOC100122327 antikoerper

Hintergrund: Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Mitotic phosphorylation of H3 Thr 3 occurs in prophase and dephosphorylation during anaphase. Haspin, a dual serine/threonine kinase, plays an important role in regulation of chromosome and spindle function during mitosis and meiosis via its function in phosphorylation of the threonine residue in the third position of histone 3 (Thr3).

Molekulargewicht: 88495

NCBI Accession: NP_114171

UniProt: Q8TF76