KIT Antikörper

Produktnummer ABIN1882197

Produktdetails anti-KIT Antikörper

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KIT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.

Immunogen: This KIT Antibody is generated from mouses immunized with human KIT recombinant protein.

Klon: 566CT8-5-4

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: IF: 1:100. IF: 1:10~50. WB: 1:100. IHC-P-Leica: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-KIT Antikörper (ABIN1882197)

Molderings, Meis, Kolck, Homann, Frieling: "Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects." in: Immunogenetics, Vol. 62, Issue 11-12, pp. 721-7, (2010) (PubMed).

Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." in: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

Chi, Chen, Zhang, Guo, Wongvipat, Shamu, Fletcher, Dewell, Maki, Zheng, Antonescu, Allis, Sawyers: "ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours." in: Nature, Vol. 467, Issue 7317, pp. 849-53, (2010) (PubMed).

Rossi, Gasparotto, Toffolatti, Pastrello, Gallina, Marzotto, Sartor, Barbareschi, Cantaloni, Messerini, Bearzi, Arrigoni, Mazzoleni, Fletcher, Casali, Talamini, Maestro, Maestra, Dei Tos: "Molecular and clinicopathologic characterization of gastrointestinal stromal tumors (GISTs) of small size." in: The American journal of surgical pathology, Vol. 34, Issue 10, pp. 1480-91, (2010) (PubMed).

Chen, Zong, Zhao, Shi: "Efficacy evaluation of imatinib treatment in patients with gastrointestinal stromal tumors: a meta-analysis." in: World journal of gastroenterology : WJG, Vol. 16, Issue 33, pp. 4227-32, (2010) (PubMed).

Details zu KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Andere Bezeichnung: KIT (KIT Produkte)

Synonyme: C-Kit antikoerper, CD117 antikoerper, PBT antikoerper, SCFR antikoerper, Bs antikoerper, Fdc antikoerper, Gsfsco1 antikoerper, Gsfsco5 antikoerper, Gsfsow3 antikoerper, SCO1 antikoerper, SCO5 antikoerper, SOW3 antikoerper, Ssm antikoerper, Tr-kit antikoerper, W antikoerper, c-KIT antikoerper, c-kit antikoerper, MGF antikoerper, KIT antikoerper, C-KIT antikoerper, kit antikoerper, receptor antikoerper, sparse antikoerper, Xkl-1 antikoerper, kit-a antikoerper, kit-b antikoerper, kl1-A antikoerper, krk1 antikoerper, pbt antikoerper, scfr antikoerper, KIT proto-oncogene receptor tyrosine kinase antikoerper, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antikoerper, KIT proto-oncogene receptor tyrosine kinase S homeolog antikoerper, KIT antikoerper, Kit antikoerper, kita antikoerper, kit antikoerper, kit.S antikoerper

Hintergrund: This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 109865

NCBI Accession: NP_000213, NP_001087241

UniProt: P10721

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity