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STAT1 Antikörper

STAT1 Reaktivität: Human WB Wirt: Maus Monoclonal 1141CT26-2-1 unconjugated
Produktnummer ABIN1882279
  • Target Alle STAT1 Antikörper anzeigen
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Reaktivität
    • 196
    • 120
    • 84
    • 22
    • 17
    • 16
    • 15
    • 13
    • 11
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Human
    Wirt
    • 179
    • 35
    • 2
    Maus
    Klonalität
    • 167
    • 49
    Monoklonal
    Konjugat
    • 120
    • 10
    • 9
    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser STAT1 Antikörper ist unkonjugiert
    Applikation
    • 153
    • 63
    • 56
    • 48
    • 40
    • 38
    • 26
    • 26
    • 20
    • 11
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    Purified His-tagged STAT1 protein was used to produced this monoclonal antibody.
    Klon
    1141CT26-2-1
    Isotyp
    IgG1
    Top Product
    Discover our top product STAT1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Schindler, Fu, Improta, Aebersold, Darnell: "Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 16, pp. 7836-9, (1992) (PubMed).

  • Target
    STAT1 (Signal Transducer and Activator of Transcription 1, 91kDa (STAT1))
    Andere Bezeichnung
    STAT1 (STAT1 Produkte)
    Hintergrund
    Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
    Molekulargewicht
    87335
    NCBI Accession
    NP_009330, NP_644671
    UniProt
    P42224
    Pathways
    JAK-STAT Signalweg, RTK Signalweg, Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, CXCR4-mediated Signaling Events
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