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YY1 Antikörper

YY1 Reaktivität: Human, Ratte, Zebrafisch (Danio rerio), Cynomolgus WB, IHC (p) Wirt: Maus Monoclonal 1183CT6-5-23-6 unconjugated
Produktnummer ABIN1882292
  • Target Alle YY1 Antikörper anzeigen
    YY1 (YY1 Transcription Factor (YY1))
    Reaktivität
    • 85
    • 41
    • 25
    • 7
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Ratte, Zebrafisch (Danio rerio), Cynomolgus
    Wirt
    • 75
    • 10
    • 1
    Maus
    Klonalität
    • 68
    • 18
    Monoklonal
    Konjugat
    • 52
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser YY1 Antikörper ist unkonjugiert
    Applikation
    • 69
    • 37
    • 27
    • 12
    • 9
    • 8
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    Purified His-tagged YY1 protein was used to produced this monoclonal antibody.
    Klon
    1183CT6-5-23-6
    Isotyp
    IgG2a
    Top Product
    Discover our top product YY1 Primärantikörper
  • Applikationshinweise
    WB: 1:500-1:1000. WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Fernando, Contreras, Zampini, Rodriguez-Malave, Alberti, Anguiano, Tran, Palanichamy, Gajeton, Ung, Aros, Waters, Casero, Basso, Pigazzi, Rao: "The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia." in: Molecular cancer, Vol. 16, Issue 1, pp. 126, (2018) (PubMed).

    Burkard, Planyavsky, Kaupe, Breitwieser, Bürckstümmer, Bennett, Superti-Furga, Colinge: "Initial characterization of the human central proteome." in: BMC systems biology, Vol. 5, pp. 17, (2011) (PubMed).

    Chen, Cai, Jin, Florens, Swanson, Washburn, Conaway, Conaway: "Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11283-9, (2011) (PubMed).

    Kim, Kim: "YY1's longer DNA-binding motifs." in: Genomics, Vol. 93, Issue 2, pp. 152-8, (2009) (PubMed).

  • Target
    YY1 (YY1 Transcription Factor (YY1))
    Andere Bezeichnung
    YY1 (YY1 Produkte)
    Synonyme
    yy1-a antikoerper, FIII antikoerper, MGC83714 antikoerper, yy1l antikoerper, zgc:64207 antikoerper, YY1 antikoerper, LOC494431 antikoerper, xyy1 antikoerper, delta antikoerper, nf-e1 antikoerper, ucrbp antikoerper, yin-yang-1 antikoerper, LOC100304682 antikoerper, ino80s antikoerper, yy1 antikoerper, DELTA antikoerper, INO80S antikoerper, NF-E1 antikoerper, UCRBP antikoerper, YIN-YANG-1 antikoerper, AW488674 antikoerper, fb59g10 antikoerper, wu:fa16g07 antikoerper, wu:fb59g10 antikoerper, YY1 transcription factor L homeolog antikoerper, YY1 transcription factor b antikoerper, YY1 transcription factor antikoerper, transcriptional repressor protein YY1 antikoerper, YY1 transcription factor S homeolog antikoerper, YY1 transcription factor a antikoerper, YY2 transcription factor antikoerper, yy1.L antikoerper, yy1b antikoerper, YY1 antikoerper, yy1 antikoerper, LOC100304682 antikoerper, yy1.S antikoerper, Yy1 antikoerper, yy1a antikoerper, YY2 antikoerper
    Hintergrund
    Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3', some genes have been shown to contain a longer binding motif allowing enhanced binding, the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. For example, it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence. May play an important role in development and differentiation. Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair, proposed to target the INO80 complex to YY1-responsive elements.
    Molekulargewicht
    44713
    NCBI Accession
    NP_003394
    UniProt
    P25490
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