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HLA-DR Beta Antikörper (AA 1-262)

HLA-DRB Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1885860
  • Target Alle HLA-DR Beta (HLA-DRB) Produkte
    HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))
    Bindungsspezifität
    AA 1-262
    Reaktivität
    Human
    Wirt
    • 2
    • 1
    Kaninchen
    Klonalität
    • 2
    • 1
    Polyklonal
    Konjugat
    • 3
    Dieser HLA-DR Beta Antikörper ist unkonjugiert
    Applikation
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    Purified by antigen-affinity chromatography.
    Immunogen
    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 262 of Human HLA-DRB4
  • Applikationshinweise
    Suggested dilutions:
    Western blotting: 1.500-1.3000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
    Konservierungsmittel
    Thimerosal (Merthiolate)
    Vorsichtsmaßnahmen
    Biohazard Informations: This product contains thimerosal which is hazardous.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Target
    HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))
    Abstract
    HLA-DRB Produkte
    Hintergrund
    HLA-DRB4 belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane.It plays a central role in the immune system by presenting peptides derived from extracellular proteins.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The beta chain is approximately 26-28 kDa and its gene contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5.The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted.There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[provided by RefSeq]
    Molekulargewicht
    30 kDa
    Gen-ID
    3126
    NCBI Accession
    NM_021983, NP_068818
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