HLA-DR Beta Antikörper (AA 1-262)

Produktnummer ABIN1885860

Produktdetails anti-HLA-DR Beta Antikörper

Target: HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))

Bindungsspezifität: AA 1-262

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HLA-DR Beta Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 262 of Human HLA-DRB4

Anwendungsinformationen

Applikationshinweise: Suggested dilutions:
Western blotting: 1.500-1.3000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: Biohazard Informations: This product contains thimerosal which is hazardous.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Details zu HLA-DR Beta

Target: HLA-DR Beta (HLA-DRB) (Major Histocompatibility Complex, Class II, DR beta (HLA-DRB))

Abstract: HLA-DRB Produkte

Hintergrund: HLA-DRB4 belongs to the HLA class II beta chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane.It plays a central role in the immune system by presenting peptides derived from extracellular proteins.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The beta chain is approximately 26-28 kDa and its gene contains 6 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities.Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5.The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted.There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.[provided by RefSeq]

Molekulargewicht: 30 kDa

Gen-ID: 3126

NCBI Accession: NM_021983, NP_068818