DR4 Antikörper (AA 1-20)

Produktnummer ABIN1886840

Produktdetails anti-DR4 Antikörper

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Bindungsspezifität: AA 1-20

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität (Details): DR4 antibody has no cross reaction to DR5.

Aufreinigung: Purified by DEAE column

Immunogen: Peptide corresponding to amino acid 1 to 20 of human DR4 mature protein.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu DR4

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Andere Bezeichnung: DR4 (DR4 Produkte)

Synonyme: APO2 antikoerper, CD261 antikoerper, DR4 antikoerper, TRAILR-1 antikoerper, TRAILR1 antikoerper, TNF receptor superfamily member 10a antikoerper, TNFRSF10A antikoerper

Hintergrund: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms.Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas.A novel death domain containing receptor was recently identified and designated DR4 (for death receptor 4).The ligand for this novel death receptor has been identified and termed TRAIL, which is a new member in the TNF family.DR4 is also called TRAIL receptor-1 (TRAIL-R1).DR4 is expressed in most of human tissues including spleen, peripheral blood leukocytes, small intestine and thymus.Like TNFR1, Fas and DR3, DR4 mediates apoptosis and NF-kappaB activation in many tissues and cells.
Synonyms: TRAIL-R1

Molekulargewicht: 57 kDa

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity