CASP9
Reaktivität: Human, Maus, Ratte
WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung
Avoid freezing and thawing repeatly.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store at 4 °C for short term use.Store at -20 °C for long term preservation.
Zhang, Yi, Liu, Zhao, Chen: "Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells." in: Journal of agricultural and food chemistry, Vol. 61, Issue 9, pp. 2188-95, (2013) (PubMed).
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3.Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.Caspase-9 is also activated by granzyme B and CPP32.Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis.Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD.Caspase-9 is expressed in a variety of human tissues. Synonyms: Mch6, Apaf-3, Casp-9