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IGF2R Antikörper (FITC)

IGF2R Reaktivität: Human, Non-Human Primate FACS Wirt: Maus Monoclonal MEM-238 FITC
Produktnummer ABIN192247
  • Target Alle IGF2R Antikörper anzeigen
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Reaktivität
    • 88
    • 36
    • 19
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    Human, Non-Human Primate
    Wirt
    • 68
    • 22
    Maus
    Klonalität
    • 67
    • 23
    Monoklonal
    Konjugat
    • 47
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IGF2R Antikörper ist konjugiert mit FITC
    Applikation
    • 35
    • 32
    • 28
    • 23
    • 14
    • 13
    • 13
    • 11
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Spezifität
    The antibody MEM-238 recognizes an extracellular epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10 % in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum.
    Kreuzreaktivität (Details)
    Human, Non-Human Primates
    Aufreinigung
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    Immunogen
    Recombinant Vaccinia virus encoding CD222.
    Klon
    MEM-238
    Isotyp
    IgG1
    Top Product
    Discover our top product IGF2R Primärantikörper
  • Applikationshinweise
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Extracellular and intracellular staining.
    Kommentare

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Rekonstitution
    No reconstitution is necessary.
    Buffer
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Do not freeze.
    Avoid prolonged exposure to light.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Schatzlmaier, Supper, Göschl, Zwirzitz, Eckerstorfer, Ellmeier, Huppa, Stockinger: "Rapid multiplex analysis of lipid raft components with single-cell resolution." in: Science signaling, Vol. 8, Issue 395, pp. rs11, (2015) (PubMed).

    Leksa, Godár, Cebecauer, Hilgert, Breuss, Weidle, Horejsí, Binder, Stockinger: "The N terminus of mannose 6-phosphate/insulin-like growth factor 2 receptor in regulation of fibrinolysis and cell migration." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40575-82, (2002) (PubMed).

  • Target
    IGF2R (Insulin-Like Growth Factor 2 Receptor (IGF2R))
    Andere Bezeichnung
    CD222 (IGF2R Produkte)
    Synonyme
    CD222 antikoerper, CIMPR antikoerper, M6P-R antikoerper, MPR1 antikoerper, MPRI antikoerper, AI661837 antikoerper, CI-MPR antikoerper, M6P/IGF2R antikoerper, Mpr300 antikoerper, mpri antikoerper, cd222 antikoerper, cimpr antikoerper, m6p-r antikoerper, insulin like growth factor 2 receptor antikoerper, insulin-like growth factor 2 receptor antikoerper, IGF2R antikoerper, Igf2r antikoerper, igf2r antikoerper
    Hintergrund
    Insulin like growth factor 2 receptorprovided,CD222 (CIMPR, cation-independent mannose 6-phosphate receptor, IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10 % of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.,IGF2R, MPR1, CIMPR, MPR300, M6P-R
    Gen-ID
    3482
    UniProt
    P11717
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