This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This FCGR3B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 12-47 amino acids from the N-terminal region of human FCGR3B.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Ravetch, Perussia: "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions." in: The Journal of experimental medicine, Vol. 170, Issue 2, pp. 481-97, (1989) (PubMed).
Peltz, Grundy, Lebo, Yssel, Barsh, Moore: "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 3, pp. 1013-7, (1989) (PubMed).
Scallon, Scigliano, Freedman, Miedel, Pan, Unkeless, Kochan: "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 13, pp. 5079-83, (1989) (PubMed).
Simmons, Seed: "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein." in: Nature, Vol. 333, Issue 6173, pp. 568-70, (1988) (PubMed).
Target
FCGR3B
(Fc Fragment of IgG, Low Affinity IIIb, Receptor (CD16b) (FCGR3B))
CD16 antikoerper, CD16b antikoerper, FCG3 antikoerper, FCGR3 antikoerper, FCR-10 antikoerper, FCRIII antikoerper, FCRIIIb antikoerper, FcRIII antikoerper, Fc fragment of IgG receptor IIIb antikoerper, Fc receptor, IgG, low affinity III antikoerper, Fc fragment of IgG receptor IIIa antikoerper, Fc-gamma RIII antikoerper, FCGR3B antikoerper, Fcgr3 antikoerper, FCGR3A antikoerper, FCGR3 antikoerper
Hintergrund
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.