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UIMC1 Antikörper (C-Term)

UIMC1 Reaktivität: Human WB, FACS Wirt: Kaninchen Polyclonal RB48354 unconjugated
Produktnummer ABIN1944736
  • Target Alle UIMC1 Antikörper anzeigen
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Bindungsspezifität
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 567-601, C-Term
    Reaktivität
    • 31
    • 8
    • 5
    Human
    Wirt
    • 28
    • 2
    • 1
    Kaninchen
    Klonalität
    • 31
    Polyklonal
    Konjugat
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser UIMC1 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1.
    Klon
    RB48354
    Isotyp
    Ig Fraction
  • Applikationshinweise
    WB: 1:1000. FC: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Yan, Kim, Jetten: "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 32379-88, (2002) (PubMed).

  • Target
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Andere Bezeichnung
    UIMC1 (UIMC1 Produkte)
    Synonyme
    UIMC1 antikoerper, RAP80 antikoerper, X2HRIP110 antikoerper, 9430016E08Rik antikoerper, D330018D10Rik antikoerper, D630032M02Rik antikoerper, RIP110 antikoerper, Rxrip110 antikoerper, RGD1307009 antikoerper, ubiquitin interaction motif containing 1 antikoerper, UIMC1 antikoerper, Uimc1 antikoerper
    Hintergrund
    Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
    Molekulargewicht
    79727
    Gen-ID
    51720
    UniProt
    Q96RL1
    Pathways
    DNA Reparatur, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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