Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Crews, Lane, Schreiber: "Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 9, pp. 4316-9, (1996) (PubMed).
Schriner, Yi, Hofmann: "cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis." in: Genomics, Vol. 34, Issue 3, pp. 317-22, (1996) (PubMed).
Vesa, Hellsten, Verkruyse, Camp, Rapola, Santavuori, Hofmann, Peltonen: "Mutations in the palmitoyl protein thioesterase gene causing infantile neuronal ceroid lipofuscinosis." in: Nature, Vol. 376, Issue 6541, pp. 584-7, (1995) (PubMed).
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.