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ATG4D Antikörper (C-Term)

ATG4D Reaktivität: Human WB, IF, IHC (p) Wirt: Kaninchen Polyclonal RB7567 unconjugated
Produktnummer ABIN1944848
  • Target Alle ATG4D Antikörper anzeigen
    ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))
    Bindungsspezifität
    • 15
    • 15
    • 8
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 441-470, C-Term
    Reaktivität
    • 61
    • 42
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 78
    • 13
    • 1
    Kaninchen
    Klonalität
    • 79
    • 13
    Polyklonal
    Konjugat
    • 28
    • 8
    • 8
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATG4D Antikörper ist unkonjugiert
    Applikation
    • 79
    • 37
    • 26
    • 26
    • 20
    • 15
    • 13
    • 6
    • 6
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This ATG4D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 441-470 amino acids from the C-terminal region of human ATG4D.
    Klon
    RB7567
    Isotyp
    Ig Fraction
  • Applikationshinweise
    IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." in: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

    Melvin: "Make Milwaukee safe for babies: the Child Welfare Commission and the development of urban health centers, 1911-1912." in: Journal of the West, Vol. 17, Issue 2, pp. 83-93, (1980) (PubMed).

    Pontén, Westermark: "Properties of human malignant glioma cells in vitro." in: Medical biology, Vol. 56, Issue 4, pp. 184-93, (1978) (PubMed).

    Westermark, Pontén, Hugosson: "Determinants for the establishment of permanent tissue culture lines from human gliomas." in: Acta pathologica et microbiologica Scandinavica. Section A, Pathology, Vol. 81, Issue 6, pp. 791-805, (1974) (PubMed).

  • Target
    ATG4D (Autophagy related 4D Cysteine Peptidase (ATG4D))
    Andere Bezeichnung
    ATG4D (ATG4D Produkte)
    Synonyme
    APG4-D antikoerper, APG4D antikoerper, AUTL4 antikoerper, 9830134P12Rik antikoerper, Apg4d antikoerper, Atg4dl antikoerper, Autl4 antikoerper, apg4d antikoerper, autophagy related 4D cysteine peptidase antikoerper, autophagy related 4D, cysteine peptidase antikoerper, autophagy related 4D, cysteine peptidase L homeolog antikoerper, ATG4D antikoerper, Atg4d antikoerper, atg4d.L antikoerper
    Hintergrund
    Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
    Molekulargewicht
    52922
    Gen-ID
    84971
    NCBI Accession
    NP_001268433, NP_116274
    UniProt
    Q86TL0
    Pathways
    Autophagie
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