EPHA2/3/4 Antikörper

Produktnummer ABIN1945089

Produktdetails anti-EPHA2/3/4 Antikörper

Target: EPHA2/3/4 (EPH Receptor A2/3/4 (EPHA2/3/4))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPHA2/3/4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF: 1:100. WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Lagerung: 4 °C,-20 °C

Referenzen für anti-EPHA2/3/4 Antikörper (ABIN1945089)

Zelinski, Zantek, Stewart, Irizarry, Kinch: "EphA2 overexpression causes tumorigenesis of mammary epithelial cells." in: Cancer research, Vol. 61, Issue 5, pp. 2301-6, (2001) (PubMed).

Miao, Burnett, Kinch, Simon, Wang: "Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation." in: Nature cell biology, Vol. 2, Issue 2, pp. 62-9, (2000) (PubMed).

Lindberg, Hunter: "cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases." in: Molecular and cellular biology, Vol. 10, Issue 12, pp. 6316-24, (1991) (PubMed).

Details zu EPHA2/3/4

Target: EPHA2/3/4 (EPH Receptor A2/3/4 (EPHA2/3/4))

Andere Bezeichnung: EPHA2/3/4 (EPHA2/3/4 Produkte)

Hintergrund: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Molekulargewicht: 108266 Da

Gen-ID: 1969

UniProt: P29317