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p53 Antikörper (AA 181-190)

TP53 Reaktivität: Human WB, IHC, IHC (p), IP, IHC (fro) Wirt: Maus Monoclonal DO-11 unconjugated

Produktnummer ABIN198283

Datenblatt (PDF)

Target Alle p53 (TP53) Antikörper anzeigen

p53 (TP53) (Tumor Protein P53 (TP53))
Bindungsspezifität
43

40

37

30

29

29

26

26

24

22

20

20

19

19

18

18

16

15

13

9

8

8

8

7

7

6

6

6

6

6

6

6

5

5

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3
AA 181-190
Reaktivität
834

255

211

107

50

34

33

19

10

9

7

6

6

3

3

3

3

2

2

2

2

1

1

1
Human
Wirt
623

228

6

2

1
Maus
Passende Sekundärantikörper
Klonalität
559

300

1
Monoklonal
Konjugat
484

38

32

19

19

13

13

13

13

13

13

13

13

13

12

12

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
Dieser p53 Antikörper ist unkonjugiert
Applikation
667

298

250

202

199

148

127

124

119

67

59

35

18

16

13

12

9

9

8

6

4

3

3

3

3

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität

Recognizes the human Cellular tumor antigen p53, also known as p53 tumor suppressor protein or NY-CO-13. p53 is a 393 amino acid ~53kD cytoplasmic/ nuclear protein up-regulated in response to DNA damage and is found in a wide variety of transformed cells. DO-11 binds to an epitope within the central region of p53 between amino acids defining a cryptic epitope exposed in unfolded/ denatured p53. Nine isoforms of human p53 are produced by alternative splicing and promoter usage, the epitope recognized by clone DO-11 is present in all isoforms. Recognizes mutant forms of p53 and has been used successfully for detection of p53 by western blotting.

Aufreinigung

Purified IgG

Immunogen

Recombinant human p53 ( AA 181-190 ).

Type of Immunogen: Recombinant protein

Klon

DO-11

Isotyp

IgG1

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Applikationshinweise

Approved: IHC, IHC-Fr, IHC-P (1:1000), IP, WB (1:1000)

Usage: Immunohistology: This product does require antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer  pH 6.0 is recommended for this purpose.

Kommentare

Target Species of Antibody: Human

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

Lot specific

Buffer

PBS,  pH 7.4, 0.09 % sodium azide.

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung

4 °C,-20 °C

Informationen zur Lagerung

4°C or -20°C, Avoid freeze-thaw cycles.
Target

p53 (TP53) (Tumor Protein P53 (TP53))

Andere Bezeichnung

TP53 / p53 (TP53 Produkte)

Hintergrund

Name/Gene ID: TP53
Family: P53

Synonyms: TP53, BCC7, Cellular tumor antigen p53, p53, TRP53, p53 tumor suppressor, Phosphoprotein p53, Antigen NY-CO-13, Tumor protein p53, Tumor suppressor p53, LFS1

Gen-ID

7157

UniProt

P04637

Pathways

p53 Signalweg, MAPK Signalweg, PI3K-Akt Signalweg, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagie, Warburg Effekt