Retinoblastoma Protein (Rb) Antikörper (Cleavage Site)
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- Target Alle Retinoblastoma Protein (Rb) (Rb Protein) Antikörper anzeigen
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
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Bindungsspezifität
- Cleavage Site
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Retinoblastoma Protein (Rb) Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC)
- Spezifität
- Recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
- Aufreinigung
- Protein G purified
- Immunogen
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A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
Type of Immunogen: Synthetic peptide - Klon
- 172C1094
- Isotyp
- IgG1
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anti-Retinoblastoma Protein (Rb Protein) (pSer780) antibodyRb Protein Reaktivität: Human ELISA, IHC, DB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) antibodyRb Protein Reaktivität: Human ELISA, IHC Wirt: Maus Monoclonal 7E4B8 unconjugated
anti-Retinoblastoma Protein (Rb Protein) (AA 251-268) antibodyRb Protein Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Affe, Schwein, Fledermaus, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (N-Term) antibodyRb Protein Reaktivität: Human, Maus, Affe WB Wirt: Kaninchen Polyclonal unconjugated
anti-Retinoblastoma Protein (Rb Protein) (C-Term) antibodyRb Protein Reaktivität: Human, Rind (Kuh), Hund, Schwein, Fledermaus, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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Approved: IHC, WB (2 μg/mL)
Not recommended for: IHC-P - Kommentare
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Target Species of Antibody: Human
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- PBS, 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-80 °C
- Informationen zur Lagerung
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Short term: 4°C
Long term: -70°C.
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- Target
- Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))
- Andere Bezeichnung
- RB1 / Retinoblastoma / RB (Rb Protein Produkte)
- Hintergrund
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Name/Gene ID: RB1
Synonyms: RB1, p105-Rb, Osteosarcoma, PRb, Retinoblastoma, Retinoblastoma 1, OSRC, RB, Pp110 - Gen-ID
- 5925
- UniProt
- P06400
- Pathways
- Mitotic G1-G1/S Phases
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