CD74 Antikörper (C-Term)
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- Target Alle CD74 Antikörper anzeigen
- CD74 (HLA-DR-gamma (CD74))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser CD74 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- Recognizes human CD74, a type II transmembrane protein, which is also known as the MHC class II associated invariant chain. The Recognizes 33, 35 and 41 kD isoforms of CD74. The CD74 Molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinoma. Expression of CD74 is primarily intracellular with moderate expression at the cell surface of B cells and monocytes. The Bu45 antibody binds to an epitope within the extracytoplasmic domain of the CD74 Molecule, which is distal from the C-terminus. *Membrane permeabilization may enhance CD74 staining. XXX recommend the use of Leucoperm (product code BUF09) for this purpose.
- Aufreinigung
- Protein G purified
- Immunogen
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B lymphoblastoid cell line HFB1.
Type of Immunogen: Cells - Klon
- BU45
- Isotyp
- IgG1
- Top Product
- Discover our top product CD74 Primärantikörper
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- Applikationshinweise
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Approved: Flo (1:25 - 1:50), IHC, IHC-Fr, IHC-P, IP
Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. - Kommentare
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Target Species of Antibody: Human
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- PBS, pH 7.4, 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- Target
- CD74 (HLA-DR-gamma (CD74))
- Andere Bezeichnung
- CD74 / CLIP (CD74 Produkte)
- Synonyme
- DHLAG antikoerper, HLADG antikoerper, II antikoerper, Ia-GAMMA antikoerper, CLIP antikoerper, Ii antikoerper, INVG34 antikoerper, Iclp-1 antikoerper, iclp1 antikoerper, wu:fb11f09 antikoerper, wu:fb12a01 antikoerper, wu:fb13d06 antikoerper, wu:fk94e07 antikoerper, Iclp-2 antikoerper, cd74 antikoerper, iclp2 antikoerper, zgc:123161 antikoerper, CD74 molecule antikoerper, CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain a antikoerper, CD74 molecule, major histocompatibility complex, class II invariant chain b antikoerper, CD74 antikoerper, Cd74 antikoerper, cd74a antikoerper, cd74b antikoerper
- Hintergrund
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Name/Gene ID: CD74
Synonyms: CD74, CD74 antigen, DHLAG, HLADG, HLA-DR-gamma, Ia-associated invariant chain, p33, MHC HLA-DR gamma chain, Ia-GAMMA - Gen-ID
- 972
- UniProt
- P04233
- Pathways
- Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints
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