SLK Antikörper (pTyr530)

Produktnummer ABIN2179275

Produktdetails anti-SLK Antikörper

Target: SLK (STE20-Like Kinase (SLK))

Bindungsspezifität: pTyr530

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SLK Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Maus, Ratte

Homologie: Human,Dog,Cow,Pig,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human FYN around the phosphorylation site of Tyr530

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu SLK

Target: SLK (STE20-Like Kinase (SLK))

Andere Bezeichnung: SLK (SLK Produkte)

Synonyme: BcDNA:LD05623 antikoerper, CG40293 antikoerper, Dmel\\CG40293 antikoerper, LD05623 antikoerper, LOSK antikoerper, STK2 antikoerper, bA16H23.1 antikoerper, se20-9 antikoerper, 9A2 antikoerper, AV021402 antikoerper, AW411554 antikoerper, Etk4 antikoerper, SMAK antikoerper, Stk2 antikoerper, mKIAA0204 antikoerper, mSLK antikoerper, STE20 like kinase antikoerper, Ste20-like kinase antikoerper, STE20-like kinase antikoerper, SLK antikoerper, Stlk antikoerper, Slk antikoerper

Hintergrund:

Synonyms: Fyn phospho Y530, p-Fyn phospho Y530, C syn protooncogene, FYN oncogene related to SRC FGR YES_ MGC45350_ OKT3 induced calcium influx regulator_ P59 FYN, Protein tyrosine kinase fyn, Proto oncogene tyrosine protein kinase fyn, Protooncogene Syn, SLK, Src like kinase, Src yes related novel gene, Src/yes related novel gene, SYN, FYN, Tyrosine kinase p59fyn T, Tyrosine kinase p59fynT.

Background: Fyn is a membrane-associated, non-receptor protein tyrosine kinase approximately 59 kDa, which belongs to the Src family of cytoplasmic tyrosine kinases. Fyn is very strongly similar to mouse Fyn, v-yes and c-src. Fyn is expressed predominately in tissues of neuronal and hematopoietic origin. Neuronal Fyn and hematopoietic Fyn differ at the junction of the SH2 and kinase domains due to tissue specific alternative splicing. Fyn has been shown to be involved in B cell and T cell activation as well as keratinocyte differentiation. In T cells, Fyn associates with the T-cell antigen receptor and Thy1. The unique N terminal domain of Fyn interacts with the CD3 and eta chains of the TcR. Fyn can bind to other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of Fyn activity. Fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation.

Gen-ID: 2534