TSPAN12 Antikörper (AA 1-100) (AbBy Fluor® 647)

Produktnummer ABIN2179834

Produktdetails anti-TSPAN12 Antikörper (AbBy Fluor® 647)

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Bindungsspezifität: AA 1-100

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TSPAN12 Antikörper ist konjugiert mit AbBy Fluor® 647

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Cow,Pig,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TSPAN12

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu TSPAN12

Target: TSPAN12 (Tetraspanin 12 (TSPAN12))

Andere Bezeichnung: TSPAN12 (TSPAN12 Produkte)

Synonyme: tm4sf12 antikoerper, zgc:63880 antikoerper, EVR5 antikoerper, NET-2 antikoerper, NET2 antikoerper, TM4SF12 antikoerper, 9030619E17 antikoerper, AI426782 antikoerper, AI663988 antikoerper, AW111457 antikoerper, Tm4sf12 antikoerper, tetraspanin-7 antikoerper, tetraspanin 12 antikoerper, LOC412465 antikoerper, TSPAN12 antikoerper, tspan12 antikoerper, Tspan12 antikoerper

Hintergrund:

Synonyms: EVR5, NET2, NET-2, TM4SF12, Tetraspanin-12, Tspan-12, Tetraspan NET-2, Transmembrane 4 superfamily member 12, TSPAN12, UNQ774/PRO1568

Background: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1) (By similarity). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity.

Gen-ID: 23554

UniProt: O95859