C5a Receptor Antikörper
C5AR
Reaktivität: Maus
FACS, WB
Wirt: Ratte
Monoclonal
10-92
unconjugated
(1 reference)-
- Target Alle C5a Receptor (C5AR) Produkte
- C5a Receptor (C5AR)
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Reaktivität
- Maus
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Wirt
- Ratte
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Klonalität
- Monoklonal
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Konjugat
- Dieser C5a Receptor Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Western Blotting (WB)
- Sterilität
- 0.2 μm filtered
- Klon
- 10-92
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- Applikationshinweise
- For immunohistology, Western blotting and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Buffer
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- Haltbarkeit
- 12 months
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: "Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody." in: Immunology letters, Vol. 88, Issue 1, pp. 47-52, (2003) (PubMed).
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: "Characterization of C5aR expression on murine myeloid and lymphoid cells by the use of a novel monoclonal antibody." in: Immunology letters, Vol. 88, Issue 1, pp. 47-52, (2003) (PubMed).
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- Target
- C5a Receptor (C5AR)
- Andere Bezeichnung
- c5a Receptor (C5AR Produkte)
- Hintergrund
- The monoclonal antibody 10/92 recognizes the mouse receptor C5a (C5aR, CD88). The mouse anaphylatoxin C5a is a 74-residu glycopolypeptide which is generated by proteolytic cleavage of the complement factor C5 in the course of complement activation. A variety of biological effects evoked by C5a could be demonstrated, rendering this molecule an important mediator of inflammation, with granulocytes and macrophages as the main target cells. All cellular responses to C5a are specifically mediated by interactions with the membrane bound C5a receptor, a seven transmembrane GTP- binding-protein-coupled receptor that belongs to the rhodopsin supergene family. The 45 kDa C5a receptor is expressed by neutrophils, monocytes/macrophages, dendritic cells, astrocytes and microglia. In contrast, C5a receptor is not detectable on resting or stimulated murine T and B lymphocytes. The monoclonal antibody 10/92 does not inhibit the binding of C5a to its receptor. Aliases C5aR1, CD88 Immunogen RBL-2H3 transfectants expressing murine C5aR
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