BLA-DQB Antikörper

Produktnummer ABIN2191836

Produktdetails anti-BLA-DQB Antikörper

Target: BLA-DQB (MHC Class II Antigen (BLA-DQB))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Sterilität: 0.2 μm filtered

Klon: ER-TR3

Anwendungsinformationen

Applikationshinweise: For immunohistology and flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-BLA-DQB Antikörper (ABIN2191836)

Van Vliet, Jenkinson, Kingston, Owen, Van Ewijk: "Stromal cell types in the developing thymus of the normal and nude mouse embryo." in: European journal of immunology, Vol. 15, Issue 7, pp. 675-81, (1985) (PubMed).

Details zu BLA-DQB

Target: BLA-DQB (MHC Class II Antigen (BLA-DQB))

Andere Bezeichnung: Major Histocompatibility Complex Class II (BLA-DQB Produkte)

Synonyme: BoLA-DQB antikoerper, DQB antikoerper, DQB1 antikoerper, OLA-DQB antikoerper, MHC class II antigen antikoerper, BLA-DQB antikoerper

Hintergrund: The monoclonal antibody ER-TR3 reacts with mouse major histocompatibitity complex class II (MHC class II), also known as I-A or I-E. MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen-presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they acquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to + CD4 T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC Class II. The monoclonal antibody ER-TR3 is a valuable tool for studying T helper cell interaction with class II positive antigen presenting cells (dendritic cells, B cells and macrophages) and for studying the development of T helper cells since they stain stromal cells in thymus. The level of antigen detected by ER-TR3 differs from strain to strain. The monoclonal antibody ER-TR3 cross reacts with human MHC class II on tonsil. Distribution of ER-TR3 among mouse strains with independent and recombinant haplotypes. Strain Haplotype