Desmoglein 2 Antikörper

Produktnummer ABIN2191994

Produktdetails anti-Desmoglein 2 Antikörper

Target: Desmoglein 2 (DSG2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Desmoglein 2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität (Details): Cross reactivity: Human desmoglein-1 : No, Human desmoglein-3 : No

Sterilität: 0.2 μm filtered

Klon: 6D8

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: For immune fluorescence and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. Positive A431 Cells control

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

Referenzen für anti-Desmoglein 2 Antikörper (ABIN2191994)

Ota, Amagai, Watanabe, Nishikawa: "No involvement of IgG autoantibodies against extracellular domains of desmoglein 2 in paraneoplastic pemphigus or inflammatory bowel diseases." in: Journal of dermatological science, Vol. 32, Issue 2, pp. 137-41, (2003) (PubMed).

Wahl, Sacco, McGranahan-Sadler, Sauppé, Wheelock, Johnson: "Plakoglobin domains that define its association with the desmosomal cadherins and the classical cadherins: identification of unique and shared domains." in: Journal of cell science, Vol. 109 ( Pt 5), pp. 1143-54, (1996) (PubMed).

Details zu Desmoglein 2

Target: Desmoglein 2 (DSG2)

Andere Bezeichnung: Desmoglein-2 (DSG2 Produkte)

Synonyme: DSG2 antikoerper, dsc antikoerper, dsga antikoerper, si:dkeyp-51f12.6 antikoerper, wu:fj23f02 antikoerper, ARVC10 antikoerper, ARVD10 antikoerper, CDHF5 antikoerper, CMD1BB antikoerper, HDGC antikoerper, AA408168 antikoerper, D18Ertd293e antikoerper, desmoglein 2 antikoerper, desmoglein 2, tandem duplicate 1 antikoerper, DSG2 antikoerper, dsg2.1 antikoerper, dsg2 antikoerper, Dsg2 antikoerper

Hintergrund: The monoclonal antibody 6D8 recognizes the extracellular domain of human desmoglein-2. Desmogleins and desmocollins are members of the cadherin family of transmembrane proteins that together make up the core of the desmosome, a structure that provides transmembrane strength to tissues undergoing mechanical stress. The desmosomal cadherins, desmogleins and desmocollins, mediate calcium-dependent cell-cell adhesion by forming homotypic and heterotypic interactions with one another. The multiprotein desmosomal complex also includes the cytoplasmic desmosomal plaque proteins plakoglobin, phakophilins, and desmoplakin, which bind to the intracellular domain of the desmogleins and function to anchor the keratin intermediate filament network to site of cell-cell contacts. In human, four desmogleins have been identified (Dsg1-4). Desmogleins are synthesized with a signal peptide that directs them to the endoplasmic reticulum and a proregion that is removed during protein processing. The mature protein includes four highly conserved extracellular domains (EC 1-4) and a fifth membrane proximal, more variable EC domain that is referred to as the "extracellular anchor domain. Desmoglein-2 is expressed on various cells including simple epithelia and myocardium, tumors and and many cell cultures. Desmogleins play critical roles in cell adhesion and skin blistering diseases, as they are the target antigens of autoimmune antibodies and bacterial toxins. Desmosomal dysfunction has been implicated in a number of diseases, including striate palmoplantar keratoderma, skin fragility, and ectodermal dysplasia, and most recently arrhythmic right ventricular cardiomyopathy (ARVC). Aliases Dsg2, Cadherin family member 5, HDGC Immunogen Extracellular EC4 domain

Pathways: Cell-Cell Junction Organization