CD96 Antikörper

Produktnummer ABIN2192060

Produktdetails anti-CD96 Antikörper

Target: CD96

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD96 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Sterilität: 0.2 μm filtered

Klon: NK92-39

Anwendungsinformationen

Applikationshinweise: For flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies in vitro dilutions have to be made according to the amounts of CD96 to be inactivated.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, containing 0.1 % bovine serum albumin.

Lagerung: 4 °C

Informationen zur Lagerung: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Haltbarkeit: 12 months

Referenzen für anti-CD96 Antikörper (ABIN2192060)

Fuchs, Cella, Giurisato, Shaw, Colonna: "Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 3994-8, (2004) (PubMed).

Details zu CD96

Target: CD96

Andere Bezeichnung: CD96 (CD96 Produkte)

Synonyme: 1700109I12Rik antikoerper, Tactile antikoerper, TACTILE antikoerper, CD96 antigen antikoerper, CD96 molecule antikoerper, Cd96 antikoerper, CD96 antikoerper

Hintergrund: The monoclonal antibody NK92.39 reacts with CD96, also known as T cell-Activated Increased Late Expression (Tactile). CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR/CD155). Furthermore, CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells. This mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. The monoclonal antibody NK92.39 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.